JAMA: Journal of the American Medical Association, 3/6/2002, Vol. 287 Issue 9, p1132, 10p, 2 charts, 5 graphs Author(s): Pope III, C. Arden; Burnett, Richard T.; Thun, Michael J.; Calle, Eugenia E.; Krewski, Daniel; Ito, Kazuhiko; Thurston, George D.

Abstract: Context: Associations have been found between day-to-day
particulate air pollution and increased risk of various adverse health
outcomes, including cardiopulmonary mortality. However, studies of
health effects of long-term particulate air pollution have been less
conclusive. Objective: To assess the relationship between long-term
exposure to fine particulate air pollution and all-cause, lung cancer,
and cardiopulmonary mortality. Design, Setting, and Participants: Vital
status and cause of death data were collected by the American Cancer
Society as part of the Cancer Prevention II study, an ongoing
prospective mortality study, which enrolled approximately 1.2 million
adults in 1982. Participants completed a questionnaire detailing
individual risk factor data (age, sex, race, weight, height, smoking
history, education, marital status, diet, alcohol consumption, and
occupational exposures). The risk factor data for approximately 500 000
adults were linked with air pollution data for metropolitan areas
throughout the United States and combined with vital status and cause of
death data through December 31, 1998. Main Outcome Measure: All-cause,
lung cancer, and cardiopulmonary mortality. Results: Fine particulate
and sulfur oxide-related pollution were associated with all-cause, lung
cancer, and cardiopulmonary mortality. Each 10-µg/m[sup 3] elevation in
fine particulate air pollution was associated with approximately a 4%,
6%, and 8% increased risk of all-cause, cardiopulmonary, and lung cancer
mortality, respectively. Measures of coarse particle fraction and total
suspended particles were not consistently associated with mortality.
Conclusion: Long-term exposure to combustion-related fine particulate
air pollution is an important environmental risk factor for
cardiopulmonary and lung cancer mortality.[ABSTRACT FROM AUTHOR]

AN: 6321356
ISSN: 0098-7484
Database: MasterFILE Select

Subject(s): AIR -- Pollution -- Health aspects; RESPIRATORY organs
-- Diseases -- Risk factors; LUNGS -- Cancer -- Risk factors;
CARDIOPULMONARY system -- Diseases -- Risk factors
Source: JAMA: Journal of the American Medical Association,
3/6/2002, Vol. 287 Issue 9, p1132, 10p, 2 charts, 5 graphs
Author(s): Pope III, C. Arden; Burnett, Richard T.; Thun, Michael
J.; Calle, Eugenia E.; Krewski, Daniel; Ito, Kazuhiko; Thurston, George
D.